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Studies show that natural progesterone cream can be used to relieve premenstrual discomforts like water retention and bloating and painful breast. In addition, this cream may relieve mood swings. Research conducted by John Lee, M.D., a doctor in California, has suggested that natural progesterone cream can be used to ease hormonal problems in premenstrual, peri-menopausal, and post-menopausal women. When scientists at the Department of Obstetrics and Genecology at St. Luke's Hospital in Pennsylvania gave natural progesterone cream to more than 100 menopausal women, more than 80% of them reported that their moods brightened and that they experienced fewer emotional problems. Researchers believe these benefits are linked to the fact that the cream helps the body balance its estrogen.